Researchers Identify Novel Protein That Explains How Biological Clocks Regulate Human Sleep


A number of experiments which were informed by observation that fruit flies could not sleep were able to identify a mutant gene which is called the "Wide Awake". Research undertaken by researchers from John Hopkins hospital has shown that the mutant gene interrupts with how the biological clock works and sets the timing for sleep.

Following isolation the gene, Mark N. Wu, the study author, and his team determined that when working properly, the gene Wide Awaake helps shut down clock neurons of the brain that control arousal by making them more responsive to signals of the inhibitory neurotransmitter called GABA.

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Image Courtesy of Grant Cochrane /

Somnowell Inventor - Visiting Professor Simon Ash FDS MSc MOrth BDS

Prof. Ash is the inventor of the highly successful SOMNOWELL Chrome device for snoring and sleep apnoea.

The Somnowell Chrome is made to exacting standards in the Somnowell laboratory under the supervision of Visiting Professor Simon Ash. Prof. Ash and his master technicians create each Somnowell Chrome device using their wealth of experience and expertise.

Prof. Ash works at the forefront of his profession. He is a Consultant and Specialist Orthodontist with over 30 years clinical experience, with a special interest in sleep related breathing disorders, TMJD, and bruxism. He currently works in Harley Street London and two private hospitals in London as part of a multi-disciplinary team managing snoring and sleep apnoea, and is Visiting Professor of Orthodontics at the BPP University.